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Title   유방암에서 포도당운반체 ( GLUT-1 ) 발현정도와 양전자단층촬영시 F-18-FDG 섭취와의 관계 ( Correlation of GLUT-1 Expression and F-18-FDG Uptake on Positron Emission Tomography in Breast Carcinoma )
Publicationinfo   2000 Jan; 032(06): 1067-1075.
Key_word   Breast neoplasm , Fluorine-18-fluorodeoxyglucose , Glucose transporter-l , Positron emission tomography
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Abstract   Purpose: Fluorine-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) has been proven to be useful in the detection of breast cancer. However, the degree of FDG uptake was variable. In this study, we evaluated the relationship between glucose transporter-1 (GLUT-1) expression with the FDG uptake in patients with breast cancer. Materials and Methods: l5 patients with proven breast cancer underwent F-18-FDG PET. After surgical resection, anti-GLUT-1 immunohistochemical staining was performed in tumor tissues to measure the GLUT-1 expression. We evaluated the correlation between semi-quantitative FDG uptake by standardized uptake value (SUV) and GLUT-1 expression. Results: In total 15 patients, there was no significant correlation between SUV and GLUT-1 expression. We separated the patients into two groups according to the tumor size. In the group of large tumor (short diameter >2 cm), there was no significant correlation. However, in the group of small tumor (short diameter < 2 cm), there was a significant correlation between the FDG uptake and GLUT-1 expression (rho=0.812, p=0.047). Conclusion: GLUT-1 expression can influence the FDG uptake in the small breast cancers. For large breast cancers, other factors as well as GLUT-1 expression may influence the FDG uptake.
저 자   천기정(Gi Jeong Cheon),정준기(June Key Chung),김보광(Bo Kwang Kim),이용진(Yong Jin Lee),노동영(Dong Young Noh),장자준(Ja June Jang),여정석(Jeong Seok Yeo),정재민(Jae Min Jeong),이동수(Dong Soo Lee),이명철(Myung Chul Lee)